Skip to content

Commit 46b5653

Browse files
committed
update vignettes
1 parent 9606d62 commit 46b5653

File tree

2 files changed

+2
-2
lines changed

2 files changed

+2
-2
lines changed

inst/extdata/motif_consistency.png

-2.68 KB
Loading

vignettes/TFregulomeR.Rmd

Lines changed: 2 additions & 2 deletions
Original file line numberDiff line numberDiff line change
@@ -43,12 +43,12 @@ source, TF source ID, number of peaks and number of peaks with motif.
4343
In TFregulomeR project, we
4444
used MEME-ChIP to perform motif de novo discovery in each ChIP-seq. Highly and centrally enriched
4545
motifs were selected and compared with the existing TFBS databases, such as HOCOMOCO and JASPAR.
46-
89 highly enriched motifs were not consistent with the TFBS databases. it might
46+
91 highly enriched motifs were not consistent with the TFBS databases. it might
4747
be due to the fact that in those cell types, the given TFs are indirectly recruited to genome,
4848
and/or that highly abundant presence of cohesion and polycomb group proteins masks the motif
4949
enrichment of the ChIP’ed TF.
5050
Besides, 136 motifs were not recorded for their corresponding TFs in the databases.
51-
In order to confirm the reliability of these 225 motifs, we used HOMER to perform a de novo motif
51+
In order to confirm the reliability of these 227 motifs, we used HOMER to perform a de novo motif
5252
discovery again. Motif results by HOMER were compared with those by MEME-ChIP and their similarity
5353
were measured by normalised Pearson correlation coefficient using compare-matrices function in
5454
RSAT with the formula: Ncor = cor * w / w_smaller,

0 commit comments

Comments
 (0)