Introducing foundational PK/PD principles with a focus on antimicrobial agents, dose optimization, and drug development
A workshop sponsored by the Gulf Coast Consortium for Antimicrobial Resistance, co-sponsored by the Consortium for Innovative Drug Discovery and Development (IDDD), and organized by the GCC AMR Scholars Program
Organizers:
Jacob K. McPherson
Special Guest Speaker: Srinivas Chamakuri
Q/A Panel:
Taryn A Eubank
Date & Location: September 30th, 10:00 AM, Bioscience Research Collaborative, 6500 Main St, Houston, TX 77030
Registration: Eventbrite
🚀 Launch the Live Quarto Presentation Hosted on GitHub Pages
📄 Download PDF Version Available in GitHub Releases
This workshop introduces trainees to the fundamental principles of pharmacokinetics and pharmacodynamics (PK/PD), with a particular emphasis on antimicrobial agents. Participants will learn how PK/PD modeling informs dose selection, regimen optimization, and the translation of preclinical findings into clinical trial design. By highlighting the role of PK/PD as a bridge between laboratory research and clinical drug development, the workshop will illustrate how these principles guide decision-making across the drug development pipeline—from candidate selection to regulatory approval.
Graduate students, pharmacy students, and postdoctoral fellows of microbiology, immunology, pharmaceutical sciences, and translational sciences.
Upon completion of this course, the participant should be able to:
- Describe the fundamental concepts of pharmacokinetics and pharmacodynamics (PK/PD).
- Discuss the design and utility of PK/PD studies, including hands-on applications using R programming.
- translate clinical PK/PD to dose optimization using R programming.
- Identify PK/PD considerations for new drug development.
| Time | Duration | Topic | Objective |
|---|---|---|---|
| 10:00 – 10:30 | 30 min | Introduction to PK/PD: in vitro hollow-fiber models (HFM), pre-clinical in vivo animal models, clinical drug therapy monitoring (DTM) | One |
| 10:30 – 11:00 | 30 min | Group-specific assignment of in vitro HFM | Two |
| 11:00 – 11:15 | 15 min | Break | — |
| 11:15 – 12:00 | 45 min | Group-specific assignment of six clinical cases | Three |
| 12:00 – 12:45 | 45 min | Lunch and Panel Q&A | — |
| 12:45 – 1:15 | 30 min | Patient presentation and suggestions for dose optimization (5 min/group) | Bonus |
| 1:15 – 2:00 | 45 min | PK/PD Considerations for Innovative Drug Discovery and Development | Bonus |
├── .github/workflows/
│ ├── render-and-deploy.yml # GitHub Pages deployment workflow
│ └── pdf-release.yml # PDF build and release workflow
├── _extensions/clean/ # Clean theme files
├── template.qmd # Main presentation file
├── _quarto.yml # Quarto project configuration
└── README.md # This file
Feel free to submit issues and enhancement requests!
This template is based on the clean theme by Grant McDermott and is available under the MIT License.